Ti-Mediated Chemoselective Conversion of Cyanoesters and Cyanoamides into β-Aminoesters and 1-Aza-spirolactams Bearing a Cyclopropane Ring
Abstract α-Cyanoesters or tertiary α-cyanoamides react with Grignard reagents and Ti(I-PrO) 4 to afford respectively β-amino esters or amides, bearing a cyclopropane ring. Starting from β- or γ-cyanoesters, spirocyclopropanelactams are formed via an in situ cyclopropanation-lactamization sequence....
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| Veröffentlicht in: | Synlett 2003, Vol.2003 (2), p.265-267 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
α-Cyanoesters or tertiary α-cyanoamides react
with Grignard reagents and Ti(I-PrO)
4
to
afford respectively β-amino esters or amides, bearing a
cyclopropane ring. Starting from β- or γ-cyanoesters,
spirocyclopropanelactams are formed via an in situ cyclopropanation-lactamization
sequence. |
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| ISSN: | 0936-5214 1437-2096 |
| DOI: | 10.1055/s-2003-36785 |