Polymer-Supported 2,2′-Bis(oxazolin-2-yl)-1,1′-binaphthyls (Boxax): Immobilized Chiral Ligands for Asymmetric Wacker-Type Cyclizations
Abstract Homochiral 2,2′-bis(oxazolin-2-yl)-1,1′-binaphthyl (boxax) ligands were anchored on various polymer supports including PS-PEG, PS, PEGA, and MeO-PEG via selective monofunctionalization at the 6-position of the binaphthyl backbone. Palladium(II) complexes of the supported boxax ligands catal...
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| Veröffentlicht in: | Synlett 2002, Vol.2002 (12), p.2049-2053 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
Homochiral 2,2′-bis(oxazolin-2-yl)-1,1′-binaphthyl (boxax)
ligands were anchored on various polymer supports including PS-PEG,
PS, PEGA, and MeO-PEG via selective monofunctionalization at the
6-position of the binaphthyl backbone. Palladium(II) complexes of
the supported boxax ligands catalyzed Wacker-type cyclization of
2-(2,3-dimethyl-2-butenyl)phenol to give 2-methyl-2-isopropenyl-2,3-dihydrobenzofuran
with up to 96% ee. |
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| ISSN: | 0936-5214 1437-2096 |
| DOI: | 10.1055/s-2002-35603 |