Synthesis and Reactivity of Aryl- and Heteroaryl-Magnesium Reagents Bearing Keto Groups

Synthesis and Reactivity of Aryl- and Heteroaryl-Magnesium Reagents Bearing Keto Groups

Abstract The reaction of iodophenyl ketones with NEO-pentylmagnesium bromide in THF or THF:NMP or THF:DMAC mixtures allows the first preparation of aryl- and heteroarylmagnesium species bearing a ketone. Under appropriate conditions, these new reagents react with a range of electrophiles, leading to...

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Veröffentlicht in:Synlett 2002, Vol.2002 (11), p.1799-1802
Hauptverfasser: Kneisel, Florian Felix, Knochel, Paul
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract The reaction of iodophenyl ketones with NEO-pentylmagnesium bromide in THF or THF:NMP or THF:DMAC mixtures allows the first preparation of aryl- and heteroarylmagnesium species bearing a ketone. Under appropriate conditions, these new reagents react with a range of electrophiles, leading to polyfunctional products.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2002-34865