Cucurbitacins from Trichosanthes kirilowii as the Inhibitory Components on Tyrosinase Activity and Melanin Synthesis of B16/F10 Melanoma Cells

Cucurbitacins from Trichosanthes kirilowii as the Inhibitory Components on Tyrosinase Activity and Melanin Synthesis of B16/F10 Melanoma Cells

Abstract Cucurbitacins 1 and 2 were isolated from the root of TRICHOSANTHES KIRILOWII by tyrosinase inhibitory activity-guided fractionation. Spectroscopic analysis revealed that compounds 1 and 2 were cucurbitacin D and 23,24-dihydro-cucurbitacin D, respectively. Compounds 1 and 2 effectively inhib...

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Veröffentlicht in:Planta medica 2002-09, Vol.68 (9), p.832-833
Hauptverfasser: Oh, Hyuncheol, Mun, Yeun-Ja, Im, Sook-Jung, Lee, Seung Yon, Song, Ho Joon, Lee, Ho-Sub, Woo, Won-Hong
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
General pharmacology
Inhibitory Concentration 50
Letter
Medical sciences
Melanins - antagonists & inhibitors
Melanins - biosynthesis
Melanoma - metabolism
Melanoma - pathology
Mice
Molecular Structure
Monophenol Monooxygenase - antagonists & inhibitors
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Roots - chemistry
Trichosanthes
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
Tumor Cells, Cultured - drug effects
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Zusammenfassung:Abstract Cucurbitacins 1 and 2 were isolated from the root of TRICHOSANTHES KIRILOWII by tyrosinase inhibitory activity-guided fractionation. Spectroscopic analysis revealed that compounds 1 and 2 were cucurbitacin D and 23,24-dihydro-cucurbitacin D, respectively. Compounds 1 and 2 effectively inhibited the activity of tyrosinase (IC 50 = 0.18 μM and 6.7 μM, respectively), and the synthesis of melanin (IC 50 = 0.16 μM and 7.5 μM, respectively) in B16/F10 melanoma cells.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2002-34418