Oxabicyclo[3.2.1]oct-6-enes as Templates for the Stereoselective Synthesis of Polypropionates: Total Synthesis of Callystatin A and C19-epi-Callystatin A
Abstract The total synthesis of the polyketide natural product callystatin A and its novel analog C19-EPI-callystatin A is described. Our strategy features the use of an enantiomerically pure oxabicyclo[3.2.1]oct-6-ene as a template for the stereocontrolled preparation of the C15-C21 polypropionate...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2002-01, Vol.2002 (14 Special Issue) |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
The total synthesis of the polyketide natural product callystatin
A and its novel analog C19-EPI-callystatin
A is described. Our strategy features the use of an enantiomerically
pure oxabicyclo[3.2.1]oct-6-ene as a template
for the stereocontrolled preparation of the C15-C21 polypropionate
region. |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-2002-34386 |