Manganese(III) Acetate-mediated Alkylation of 1,3-Dicarbonyls to Form Tricarbonyl Compounds Bearing a Quaternary Carbon Centre

Manganese(III) Acetate-mediated Alkylation of 1,3-Dicarbonyls to Form Tricarbonyl Compounds Bearing a Quaternary Carbon Centre

Abstract 1,3-Dicarbonyl compounds including ethyl 2-methylacetoacetate can be efficiently alkylated with enol ethers or enol esters in the presence of manganese(III) acetate. These intermolecular radical addition reactions can be used to form sterically congested quaternary carbon centres in excelle...

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Veröffentlicht in:Synlett 2002-07, Vol.2002 (7), p.1069-1072
Hauptverfasser: Bar, Gregory, Parsons, Andrew F., Thomas, C. Barry
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract 1,3-Dicarbonyl compounds including ethyl 2-methylacetoacetate can be efficiently alkylated with enol ethers or enol esters in the presence of manganese(III) acetate. These intermolecular radical addition reactions can be used to form sterically congested quaternary carbon centres in excellent yield (81-97%).
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2002-32576