Flavonoids with Activity against Methicillin-Resistant Staphylococcus aureus from Dalea scandens var. paucifolia

Abstract Bioassay-guided fractionation of the ethyl acetate extract of the roots of DALEA SCANDENS (Miller) R. Clausen var. PAUCIFOLIA led to the isolation of new flavonoids, 2(S)-5′-(-1′″,1″′-dimethylallyl)-8-(3″,3″-dimethylallyl)-2′,4′,5,7-tetrahydroxyflavanone, 2(S)-5′-(1″′,1″′-dimethylallyl)-8-(3″,3″-dimethylallyl)-2′-methoxy-4′,5,7-trihydroxyflavanone and 5′-(1″′,1″′-dimethylallyl)-8-(3″,3″-dimethylallyl)-2′,4′,5,7-tetrahydroxyflavone. Structure elucidation was carried out by spectroscopic methods. All three compounds showed significant activity against both methicillin-susceptible and methicillin-resistant STAPHYLOCOCCUS AUREUS.