A New, General Entry to 3,5-Unsubstituted 4-O-Alkyl Tetramates

A New, General Entry to 3,5-Unsubstituted 4-O-Alkyl Tetramates

Abstract A variety of 3,5-unsubstituted 4-O-benzyl tetramates 10 was prepared in good overall yield from methyl (E)-3-benzyloxy-4-oxobut-2-enoate 7 by a reductive amination-lactamization sequence. An efficient approach to this building block as well as to various 3-alkoxy analogues is presented.

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Veröffentlicht in:Synthesis (Stuttgart) 2002, Vol.2002 (7), p.869-874
Hauptverfasser: Paintner, Franz F., Metz, Marcel, Bauschke, Gerd
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A variety of 3,5-unsubstituted 4-O-benzyl tetramates 10 was prepared in good overall yield from methyl (E)-3-benzyloxy-4-oxobut-2-enoate 7 by a reductive amination-lactamization sequence. An efficient approach to this building block as well as to various 3-alkoxy analogues is presented.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2002-28522