New Macrocyclic Diterpenoids from Euphorbia esula

Abstract The structures of two new macrocyclic jatrophane diterpenoid esters from the whole herb of EUPHORBIA ESULA, were established as 11,14-epoxy-3β,5α,7β,8α,9α,15β-hexaacetoxy-12-oxo-13αH-jatropha-6(17)-ene (1) and 1α,3β-diacetoxy-5α,7β-dibenzoyloxy-9,14-dioxo-11β,12α-epoxy-2α,8α,15β-trihydroxy-...

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Veröffentlicht in:	Planta medica 2002-03, Vol.68 (3), p.244-248
Hauptverfasser:	Liu, L. G., Meng, J. C., Wu, S. X., Li, X. Y., Zhao, X. C., Tan, R. X.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Assay Diterpenes - chemistry Diterpenes - isolation & purification Euphorbia General pharmacology HL-60 Cells Humans Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Original Paper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Tumor Cells, Cultured
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Zusammenfassung:	Abstract The structures of two new macrocyclic jatrophane diterpenoid esters from the whole herb of EUPHORBIA ESULA, were established as 11,14-epoxy-3β,5α,7β,8α,9α,15β-hexaacetoxy-12-oxo-13αH-jatropha-6(17)-ene (1) and 1α,3β-diacetoxy-5α,7β-dibenzoyloxy-9,14-dioxo-11β,12α-epoxy-2α,8α,15β-trihydroxy-13βH-jatropha-6(17)-ene (2) by a combination of 1D- and 2D-NMR techniques as well as UV, IR and mass spectral data. Bioassay evaluation of all isolates against the human tumor cell lines (B16, KB, SMMC and BGC) indicated that ester 2 was cytotoxic to B16 with the IC 50 value being 1.81 μg/ml. In addition, the irritant activity assay indicated that both diterpenoids were inactive (ID 24 50 > 100 μg/ear).
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2002-23135