Optimized Synthesis of an Orthogonally Protected Glucosamine

Optimized Synthesis of an Orthogonally Protected Glucosamine

Abstract Glucosamine hydrochloride was transformed into an orthogonally protected intermediate in seven steps and 34% over­all yield. The synthesis includes an optimized preparation of N-phthaloyl-β-D-glucosamine tetraacetate, a commonly used precursor in carbohydrate chemistry.

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Veröffentlicht in:Synthesis (Stuttgart) 2002, Vol.2002 (4), p.487-490
Hauptverfasser: Hernández-Torres, Jesús M., Liew, Siong-Tern, Achkar, Jihane, Wei, Alexander
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Glucosamine hydrochloride was transformed into an orthogonally protected intermediate in seven steps and 34% over­all yield. The synthesis includes an optimized preparation of N-phthaloyl-β-D-glucosamine tetraacetate, a commonly used precursor in carbohydrate chemistry.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2002-20962