Regioselective Hydroxylation of 2,4-Lutidine: A Practical Synthesis of 4-Hydroxymethyl-2-methylpyridine

Regioselective Hydroxylation of 2,4-Lutidine: A Practical Synthesis of 4-Hydroxymethyl-2-methylpyridine

Abstract A practical synthesis of 4-hydroxymethyl-2-methylpyridine has been developed which makes use of Evans’ regioselective lithiation of readily available 2,4-lutidine and trapping with dimethylformamide.

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Veröffentlicht in:Synthesis (Stuttgart) 2002, Vol.2002 (4), p.483-486
Hauptverfasser: Ragan, John A., Jones, Brian P., Meltz, Clifford N., Teixeira, John J.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A practical synthesis of 4-hydroxymethyl-2-methylpyridine has been developed which makes use of Evans’ regioselective lithiation of readily available 2,4-lutidine and trapping with dimethylformamide.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2002-20960