A Convenient Route to Alkaloid Lipids: Application for the Synthesis of a Leptophylline A Analogue
Abstract A synthetic route for efficient access to alkaloid lipids, using the chiral 2,3,6-trisubstituted piperidine acetaldehyde 9 as an intermediate, is reported. The utility of the synthetic route was demonstrated in the asymmetric synthesis of an unnatural analogue of CASSIA LEPTOPHYLLA alkaloid...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2002-01, Vol.2002 (1) |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
A synthetic route for efficient access to alkaloid lipids, using the chiral 2,3,6-trisubstituted piperidine acetaldehyde 9 as an intermediate, is reported. The utility of the synthetic route was demonstrated in the asymmetric synthesis of an unnatural analogue of CASSIA LEPTOPHYLLA alkaloid lipid, LEPTOPHYLLIN A, in 16 steps and 15% overall yield starting from D-glucal. |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-2002-19302 |