LiClO4-Catalyzed One-Pot Synthesis of Dihydropyrimidinones: An Improved Protocol for Biginelli Reaction
Abstract Lithium perchlorate efficiently catalyzes the three-component condensation reaction of aldehyde, β-keto ester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yields under neutral conditions. LiOTf is also found to be an efficient catalyst for the...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2001, Vol.2001 (9), p.1341-1345 |
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| container_end_page | 1345 |
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| container_issue | 9 |
| container_start_page | 1341 |
| container_title | Synthesis (Stuttgart) |
| container_volume | 2001 |
| creator | Yadav, Jhillu S. Subba Reddy, Basi V. Srinivas, R. Venugopal, C. Ramalingam, T. |
| description | Abstract
Lithium perchlorate efficiently catalyzes the three-component condensation reaction of aldehyde, β-keto ester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yields under neutral conditions. LiOTf is also found to be an efficient catalyst for the synthesis of dihydropyrimidinones from aldehyde, β-keto ester and urea. |
| doi_str_mv | 10.1055/s-2001-15229 |
| format | Article |
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Lithium perchlorate efficiently catalyzes the three-component condensation reaction of aldehyde, β-keto ester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yields under neutral conditions. LiOTf is also found to be an efficient catalyst for the synthesis of dihydropyrimidinones from aldehyde, β-keto ester and urea.</description><identifier>ISSN: 0039-7881</identifier><identifier>EISSN: 1437-210X</identifier><identifier>DOI: 10.1055/s-2001-15229</identifier><language>eng</language><ispartof>Synthesis (Stuttgart), 2001, Vol.2001 (9), p.1341-1345</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-9012f5429166424f83e269f2b27d207d58ea35aa11560b52ff526aa791b59c263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-15229.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2001-15229$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3004,3005,4010,27900,27901,27902,54534,54535</link.rule.ids></links><search><creatorcontrib>Yadav, Jhillu S.</creatorcontrib><creatorcontrib>Subba Reddy, Basi V.</creatorcontrib><creatorcontrib>Srinivas, R.</creatorcontrib><creatorcontrib>Venugopal, C.</creatorcontrib><creatorcontrib>Ramalingam, T.</creatorcontrib><title>LiClO4-Catalyzed One-Pot Synthesis of Dihydropyrimidinones: An Improved Protocol for Biginelli Reaction</title><title>Synthesis (Stuttgart)</title><addtitle>Synthesis</addtitle><description>Abstract
Lithium perchlorate efficiently catalyzes the three-component condensation reaction of aldehyde, β-keto ester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yields under neutral conditions. LiOTf is also found to be an efficient catalyst for the synthesis of dihydropyrimidinones from aldehyde, β-keto ester and urea.</description><issn>0039-7881</issn><issn>1437-210X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNptkMtOwzAURC0EEqWw4wO8B4N9HScxuxJelSq14iGxi9zEbl2ldmUbpPD1pMCS1WzOjEYHoXNGrxgV4joSoJQRJgDkARqxjBcEGH0_RCNKuSRFWbJjdBLjhlJaAJcjtJrZqptnpFJJdf2XbvHcabLwCb_0Lq11tBF7g-_sum-D3_XBbm1rnXc63uCJw9PtLvjPobYIPvnGd9j4gG_tyjrddRY_a9Uk690pOjKqi_rsL8fo7eH-tXois_njtJrMSMO5SERSBkZkIFmeZ5CZkmvIpYElFC3QohWlVlwoxZjI6VKAMQJypQrJlkI2kPMxuvzdbYKPMWhT74bLKvQ1o_VeUh3rvaT6R9KAX_ziaW31Vtcb_xHc8O9_-huENWdX</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Yadav, Jhillu S.</creator><creator>Subba Reddy, Basi V.</creator><creator>Srinivas, R.</creator><creator>Venugopal, C.</creator><creator>Ramalingam, T.</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2001</creationdate><title>LiClO4-Catalyzed One-Pot Synthesis of Dihydropyrimidinones: An Improved Protocol for Biginelli Reaction</title><author>Yadav, Jhillu S. ; Subba Reddy, Basi V. ; Srinivas, R. ; Venugopal, C. ; Ramalingam, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-9012f5429166424f83e269f2b27d207d58ea35aa11560b52ff526aa791b59c263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yadav, Jhillu S.</creatorcontrib><creatorcontrib>Subba Reddy, Basi V.</creatorcontrib><creatorcontrib>Srinivas, R.</creatorcontrib><creatorcontrib>Venugopal, C.</creatorcontrib><creatorcontrib>Ramalingam, T.</creatorcontrib><collection>CrossRef</collection><jtitle>Synthesis (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yadav, Jhillu S.</au><au>Subba Reddy, Basi V.</au><au>Srinivas, R.</au><au>Venugopal, C.</au><au>Ramalingam, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LiClO4-Catalyzed One-Pot Synthesis of Dihydropyrimidinones: An Improved Protocol for Biginelli Reaction</atitle><jtitle>Synthesis (Stuttgart)</jtitle><addtitle>Synthesis</addtitle><date>2001</date><risdate>2001</risdate><volume>2001</volume><issue>9</issue><spage>1341</spage><epage>1345</epage><pages>1341-1345</pages><issn>0039-7881</issn><eissn>1437-210X</eissn><abstract>Abstract
Lithium perchlorate efficiently catalyzes the three-component condensation reaction of aldehyde, β-keto ester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yields under neutral conditions. LiOTf is also found to be an efficient catalyst for the synthesis of dihydropyrimidinones from aldehyde, β-keto ester and urea.</abstract><doi>10.1055/s-2001-15229</doi><tpages>5</tpages></addata></record> |
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| ispartof | Synthesis (Stuttgart), 2001, Vol.2001 (9), p.1341-1345 |
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| language | eng |
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| title | LiClO4-Catalyzed One-Pot Synthesis of Dihydropyrimidinones: An Improved Protocol for Biginelli Reaction |
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