LiClO4-Catalyzed One-Pot Synthesis of Dihydropyrimidinones: An Improved Protocol for Biginelli Reaction

LiClO4-Catalyzed One-Pot Synthesis of Dihydropyrimidinones: An Improved Protocol for Biginelli Reaction

Abstract Lithium perchlorate efficiently catalyzes the three-component condensation reaction of aldehyde, β-keto ester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yields under neutral conditions. LiOTf is also found to be an efficient catalyst for the...

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Veröffentlicht in:Synthesis (Stuttgart) 2001, Vol.2001 (9), p.1341-1345
Hauptverfasser: Yadav, Jhillu S., Subba Reddy, Basi V., Srinivas, R., Venugopal, C., Ramalingam, T.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Lithium perchlorate efficiently catalyzes the three-component condensation reaction of aldehyde, β-keto ester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yields under neutral conditions. LiOTf is also found to be an efficient catalyst for the synthesis of dihydropyrimidinones from aldehyde, β-keto ester and urea.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2001-15229