Lignans as Anti-Tumor-Promoter from the Seeds of Hernandia ovigera

Abstract Seven lignans (2 - 8) isolated from the seeds of HERNANDIA OVIGERA L. (Hernandiaceae) were tested for their inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. Using a primary screening test, all the lignans showed...

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Veröffentlicht in:	Planta medica 2001-03, Vol.67 (2), p.166-168
Hauptverfasser:	Ito, Chihiro, Itoigawa, Masataka, Ogata, Masakazu, Mou, Xiao Yang, Tokuda, Harukuni, Nishino, Hoyoku, Furukawa, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticarcinogenic Agents - isolation & purification Anticarcinogenic Agents - therapeutic use Antigens, Viral - drug effects Biological and medical sciences General pharmacology Humans Letter Lignans - isolation & purification Lignans - therapeutic use Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Seeds - chemistry Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured - drug effects
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Zusammenfassung:	Abstract Seven lignans (2 - 8) isolated from the seeds of HERNANDIA OVIGERA L. (Hernandiaceae) were tested for their inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. Using a primary screening test, all the lignans showed inhibitory activity with IC 50 470 - 590 mol ratio/32 pmol TPA. The data demonstrated that these lignans might be valuable anti-tumor-promoters.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2001-11501