Plasma Concentrations of Clozapine and its Major Metabolites During Combined Treatment with Paroxetine or Sertraline

The effect of paroxetine or sertraline on steady-state plasma concentrations of clozapine and its major metabolites was studied in 17 patients with schizophrenia or schizoaffective disorder stabilized on clozapine therapy (200-400 mg/day). In order to treat negative symptomatology or concomitant dep...

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Veröffentlicht in:	Pharmacopsychiatry 2000-11, Vol.33 (6), p.213-217
Hauptverfasser:	Spina, E., Avenoso, A., Salemi, M., Facciolá, G., Scordo, M. G., Ancione, M., Madia, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Clozapine - blood Clozapine - pharmacokinetics Drug Interactions Drug Therapy, Combination Female Humans Male Medical sciences Middle Aged Neuropharmacology Original Paper Paroxetine - administration & dosage Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Psychotic Disorders - drug therapy Schizophrenia - drug therapy Serotonin Antagonists - blood Serotonin Antagonists - pharmacokinetics Serotonin Uptake Inhibitors - administration & dosage Sertraline - administration & dosage
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