Plasma Concentrations of Clozapine and its Major Metabolites During Combined Treatment with Paroxetine or Sertraline

The effect of paroxetine or sertraline on steady-state plasma concentrations of clozapine and its major metabolites was studied in 17 patients with schizophrenia or schizoaffective disorder stabilized on clozapine therapy (200-400 mg/day). In order to treat negative symptomatology or concomitant dep...

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Veröffentlicht in:Pharmacopsychiatry 2000-11, Vol.33 (6), p.213-217
Hauptverfasser: Spina, E., Avenoso, A., Salemi, M., Facciolá, G., Scordo, M. G., Ancione, M., Madia, A.
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Sprache:eng
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Zusammenfassung:The effect of paroxetine or sertraline on steady-state plasma concentrations of clozapine and its major metabolites was studied in 17 patients with schizophrenia or schizoaffective disorder stabilized on clozapine therapy (200-400 mg/day). In order to treat negative symptomatology or concomitant depression, 9 patients received additional paroxetine (20-40mg/day) and 8 patients sertraline (50-100 mg/day). After 3 weeks of paroxetine administration, mean plasma concentrations of clozapine and norclozapine increased significantly by 31% (p
ISSN:0176-3679
1439-0795
DOI:10.1055/s-2000-8361