1,3-Dipolar Cycloaddition of 3-Amino Oxindole-Based Azomethine Ylides and O-Vinylphosphonylated Salicylaldehydes for Diastereoselective Synthesis of Oxindole Spiro-P,N-polycyclic Heterocycles
Abstract An efficient stereoselective assembly strategy for the construction of pyrrolidin-2,3′-oxindole cis -fused phosphadihydrocoumarins was established. The process involves the condensation of O-vinylphosphonylated salicylaldehydes and 3-amino oxindoles followed by intermolecular cycloaddition...
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Veröffentlicht in: | Synthesis (Stuttgart) 2020-05, Vol.52 (9), p.1387-1397 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Abstract
An efficient stereoselective assembly strategy for the construction of pyrrolidin-2,3′-oxindole
cis
-fused phosphadihydrocoumarins was established. The process involves the condensation of O-vinylphosphonylated salicylaldehydes and 3-amino oxindoles followed by intermolecular cycloaddition with high diastereoselectivity and atom economy. |
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ISSN: | 0039-7881 1437-210X |
DOI: | 10.1055/s-0039-1691597 |