Role of α5β1 and αvβ3 Integrins on Smooth Muscle Cell Spreading and Migration in Fibrin Gels

Summary Fibrin is found at sites of vascular injury and is one of the major matrix ligands for β3 integrins. Blocking the β3 integrin on smooth muscle cell is hypothesized as a potential target to prevent restenosis because it could inhibit cell attachment and migration into fibrin provisional matri...

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Veröffentlicht in:	Thrombosis and haemostasis 2000, Vol.83 (4), p.701-705
Hauptverfasser:	Ikari, Yuji, Yee, Karen O., Schwartz, Stephen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Medical sciences Review Article Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
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Zusammenfassung:	Summary Fibrin is found at sites of vascular injury and is one of the major matrix ligands for β3 integrins. Blocking the β3 integrin on smooth muscle cell is hypothesized as a potential target to prevent restenosis because it could inhibit cell attachment and migration into fibrin provisional matrix. Human aortic smooth muscle cells (HNB18E6E7) spread stably in plasma gels within 24 h. Cell spreading was dramatically blocked by simultaneous use of α5β1 and αvβ3 integrin antibodies (P
ISSN:	0340-6245 2567-689X
DOI:	10.1055/s-0037-1614090