First Total Synthesis of 7-Isovaleryloxy-8-methoxygirinimbine

First Total Synthesis of 7-Isovaleryloxy-8-methoxygirinimbine

Abstract We describe the first total synthesis of the pyrano[3,2- a ]carbazole alkaloid 7-isovaleryloxy-8-methoxygirinimbine, using a palladium(II)-catalyzed double C–H-bond activation for construction of the carbazole framework and a phenylboronic acid catalyzed annulation of the pyran ring as key...

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Veröffentlicht in:Synthesis (Stuttgart) 2018-07, Vol.50 (13), p.2516-2522
Hauptverfasser: Brütting, Christian, Schmidt, Arndt W., Kataeva, Olga, Knölker, Hans-Joachim
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract We describe the first total synthesis of the pyrano[3,2- a ]carbazole alkaloid 7-isovaleryloxy-8-methoxygirinimbine, using a palladium(II)-catalyzed double C–H-bond activation for construction of the carbazole framework and a phenylboronic acid catalyzed annulation of the pyran ring as key steps.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0037-1609717