Synthesis of 1,3,4-Oxadiazoles via Annulation of Hydrazides and Benzene-1,3,5-triyl Triformate under Metal-Free Conditions

Synthesis of 1,3,4-Oxadiazoles via Annulation of Hydrazides and Benzene-1,3,5-triyl Triformate under Metal-Free Conditions

Abstract A new and efficient method for the synthesis of 1,3,4-oxadiazoles via the annulation of hydrazides with benzene-1,3,5-triyl triformate (TFBen) under metal-free conditions is reported. A broad range of hydrazides were transformed into the corresponding 1,3,4-oxadiazoles in good yields with e...

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Veröffentlicht in:Synthesis (Stuttgart) 2018-08, Vol.50 (16), p.3238-3242
Hauptverfasser: Yin, Zhiping, Power, Dennis J., Wang, Zechao, Stewart, Scott G., Wu, Xiao-Feng
Format: Artikel
Sprache:eng
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special topic
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Zusammenfassung:Abstract A new and efficient method for the synthesis of 1,3,4-oxadiazoles via the annulation of hydrazides with benzene-1,3,5-triyl triformate (TFBen) under metal-free conditions is reported. A broad range of hydrazides were transformed into the corresponding 1,3,4-oxadiazoles in good yields with excellent functional group tolerance.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0037-1609481