Synthesis of Monofluoroalkenes: A Leap Forward

Abstract Monofluoroalkenes have found wide application in organic chemistry, medicinal chemistry, and materials science. This review summarizes the most recent advances made regarding the preparation of monofluoroalkenes, covering the period between October 2010 and September 2017. This review is divided in three main parts, one for each possible substitution pattern, namely di-, tri-, and tetrasubstituted. Then, for each class, further subclassification is made according to the reaction type. 1 Introduction 2 Disubstituted Monofluoroalkenes 2.1 Disubstituted α-Monofluoroalkenes 2.2 Disubstituted β-Monofluoroalkenes 3 Trisubstituted Monofluoroalkenes 4 Tetrasubstituted Monofluoroalkenes 5 Conclusions