Tethered NHC Ligands for Stereoselective Alkyne Semihydrogenations
Abstract A copper(I)-catalyzed semihydrogenation of internal alkynes has been developed. A variety of oxygen- and nitrogen-tethered N-heterocyclic carbene (NHC) complexes have been investigated, leading to a highly Z -selective transformation. The catalyst is generated from inexpensive copper(I) chl...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2017-06, Vol.49 (11), p.2470-2482 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
A copper(I)-catalyzed semihydrogenation of internal alkynes has been developed. A variety of oxygen- and nitrogen-tethered N-heterocyclic carbene (NHC) complexes have been investigated, leading to a highly
Z
-selective transformation. The catalyst is generated from inexpensive copper(I) chloride in situ and allows catalytic semihydrogenation down to 10 bar H
2
. |
|---|---|
| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-0036-1590112 |