Claisen Rearrangements of Benzyl Vinyl Ethers and Heterobenzyl Vinyl Ethers
Abstract The Claisen rearrangement of benzylic substrates (benzyl vinyl ethers) has received considerably less attention than its well-known aliphatic and normal aromatic variants. Here, we review the rearrangement of both benzylic and heterobenzylic substrates, with examples of the reaction’s use...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2018-05, Vol.50 (9), p.1750-1772 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
The Claisen rearrangement of benzylic substrates (benzyl vinyl ethers) has received considerably less attention than its well-known aliphatic and normal aromatic variants. Here, we review the rearrangement of both benzylic and heterobenzylic substrates, with examples of the reaction’s use in the synthesis of natural products and drug-like molecules.
1 Introduction
2 Early Attempts at the Benzyl-Claisen Rearrangement
3 Successful Benzylic Examples
4 Heterobenzylic Examples
5 Conclusion |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-0036-1589529 |