Enolizable Alkylidene Heterocyclic and Carbocyclic Carbonyl Systems­: Valuable Vinylogous Donor Substrates in Synthesis

Abstract Controlled vinylogous carbon–carbon bond-forming reactions are useful options for providing the selective remote functionalization of conjugated carbonyl substrates. Remotely enolizable alkylidene heterocyclic and carbocyclic carbonyl compounds are pro-nucleophilic substrates that may be engaged in highly valuable chemical transformations. This review emphasizes the merits of these recently discovered vinylogous donors in the chemo-, regio- and stereoselective synthesis of many functionality-rich products. 1 Introduction 2 Alkylidene Oxindoles 3 Alkylidene Pyrazolinones 4 Alkylidene Furanones 5 Alkylidene Azlactones 6 Cycloalkylidene Carbonyl Compounds 7 Alkylidene Indenones 8 Cycloalkylidene Malononitriles 9 Conclusion