First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine

First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine

Abstract A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in the total synth...

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Veröffentlicht in:Synthesis (Stuttgart) 2017-06, Vol.49 (12), p.2768-2774
Hauptverfasser: Puvvala, Srinu, Jadhav, Vinod D., Narkhede, Umesh C., Anji Karun, M. V. V. S. R. N., Venkata Ramana Reddy, Ch
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Sprache:eng
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Zusammenfassung:Abstract A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in the total synthesis of a cytotoxic aaptamine derivative.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0036-1588752