An Efficient and Modular Route to C3-TunePhos-Type Ligands

Abstract An efficient and modular synthetic route to the bidentate C 3 *-TunePhos was developed, which allowed tunable steric and electronic effects of the ligands. This novel chemical technology highlights a versatile C 3 *-dibromodiphenyl intermediate that was accomplished by in situ Grignard exchange and subsequent Cu(II)-mediated intra­molecular oxidative radical coupling process. It is worth noting that this advanced intermediate not only could be easily prepared by a diverse array of C 3 *-TunePhos-type ligands, but also could be used to facile synthesis of other novel type of N,S-centered bidentate ligands.