Synthesis of N-Aryl Amides by Ligand-Free Copper-Catalyzed ipso-Amidation of Arylboronic Acids with Nitriles

Synthesis of N-Aryl Amides by Ligand-Free Copper-Catalyzed ipso-Amidation of Arylboronic Acids with Nitriles

Abstract A facile copper-catalyzed ipso -amidation of arylboronic acids with nitriles has been developed. The method provides a highly efficient and economical synthesis of N -aryl amides with a broad substrate scope.

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Veröffentlicht in:Synthesis (Stuttgart) 2016-12, Vol.49 (8), p.1834-1838
Hauptverfasser: Qiao, Yan, Li, Gaoqiang, Liu, Sha, Yangkai, Yujie, Tu, Jingxuan, Xu, Feng
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A facile copper-catalyzed ipso -amidation of arylboronic acids with nitriles has been developed. The method provides a highly efficient and economical synthesis of N -aryl amides with a broad substrate scope.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0036-1588373