Synergistic Catalysis: Asymmetric Synthesis of Cyclopentanes Bearing Four Stereogenic Centers

Synergistic Catalysis: Asymmetric Synthesis of Cyclopentanes Bearing Four Stereogenic Centers

Abstract We present a formal [3+2] cycloaddition based on synergistic catalysis. Vinylcyclopropanes derived from cyanoesters react with enals by dual activation using palladium(0) and secondary amines to form the corresponding cyclopentanes in good yields and stereoselectivities.

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Veröffentlicht in:Synthesis (Stuttgart) 2016-12, Vol.49 (1), p.167-174
Hauptverfasser: Zhang, Kaiheng, Meazza, Marta, Izaga, Anabel, Contamine, Clotilde, Gimeno, M. Concepción, Herrera, Raquel P., Rios, Ramon
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract We present a formal [3+2] cycloaddition based on synergistic catalysis. Vinylcyclopropanes derived from cyanoesters react with enals by dual activation using palladium(0) and secondary amines to form the corresponding cyclopentanes in good yields and stereoselectivities.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0036-1588347