Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin
Abstract The total synthesis of biselide A based on our earlier strategy of synthesizing haterumalides is reported. The highlights of this approach are the use of regioselective enzymatic hydrolysis for the installation of a C20 oxygen functional group and an asymmetric aldol reaction for the stereo...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2017-07, Vol.49 (13), p.2958-2970 |
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| container_issue | 13 |
| container_start_page | 2958 |
| container_title | Synthesis (Stuttgart) |
| container_volume | 49 |
| creator | Hayakawa, Ichiro Okamura, Masami Suzuki, Kazuaki Shimanuki, Mami Kimura, Kizuku Yamada, Takuya Ohyoshi, Takayuki Kigoshi, Hideo |
| description | Abstract
The total synthesis of biselide A based on our earlier strategy of synthesizing haterumalides is reported. The highlights of this approach are the use of regioselective enzymatic hydrolysis for the installation of a C20 oxygen functional group and an asymmetric aldol reaction for the stereoselective introduction of a C3 oxygen functional group. |
| doi_str_mv | 10.1055/s-0036-1588169 |
| format | Article |
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The total synthesis of biselide A based on our earlier strategy of synthesizing haterumalides is reported. The highlights of this approach are the use of regioselective enzymatic hydrolysis for the installation of a C20 oxygen functional group and an asymmetric aldol reaction for the stereoselective introduction of a C3 oxygen functional group.</description><identifier>ISSN: 0039-7881</identifier><identifier>EISSN: 1437-210X</identifier><identifier>DOI: 10.1055/s-0036-1588169</identifier><language>eng</language><publisher>Stuttgart · New York: Georg Thieme Verlag</publisher><ispartof>Synthesis (Stuttgart), 2017-07, Vol.49 (13), p.2958-2970</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-3262fb24c158cf0f5cc815b5e2b95bbfd2662588b96ec4d42e64d7532a6997fa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1588169.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0036-1588169$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3017,3018,27924,27925,54559,54560</link.rule.ids></links><search><creatorcontrib>Hayakawa, Ichiro</creatorcontrib><creatorcontrib>Okamura, Masami</creatorcontrib><creatorcontrib>Suzuki, Kazuaki</creatorcontrib><creatorcontrib>Shimanuki, Mami</creatorcontrib><creatorcontrib>Kimura, Kizuku</creatorcontrib><creatorcontrib>Yamada, Takuya</creatorcontrib><creatorcontrib>Ohyoshi, Takayuki</creatorcontrib><creatorcontrib>Kigoshi, Hideo</creatorcontrib><title>Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin</title><title>Synthesis (Stuttgart)</title><addtitle>Synthesis</addtitle><description>Abstract
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The total synthesis of biselide A based on our earlier strategy of synthesizing haterumalides is reported. The highlights of this approach are the use of regioselective enzymatic hydrolysis for the installation of a C20 oxygen functional group and an asymmetric aldol reaction for the stereoselective introduction of a C3 oxygen functional group.</abstract><cop>Stuttgart · New York</cop><pub>Georg Thieme Verlag</pub><doi>10.1055/s-0036-1588169</doi><tpages>13</tpages></addata></record> |
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| ispartof | Synthesis (Stuttgart), 2017-07, Vol.49 (13), p.2958-2970 |
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| source | Thieme Connect Journals |
| title | Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin |
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