Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin

Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin

Abstract The total synthesis of biselide A based on our earlier strategy of synthesizing haterumalides is reported. The highlights of this approach are the use of regioselective enzymatic hydrolysis for the installation of a C20 oxygen functional group and an asymmetric aldol reaction for the stereo...

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Veröffentlicht in:Synthesis (Stuttgart) 2017-07, Vol.49 (13), p.2958-2970
Hauptverfasser: Hayakawa, Ichiro, Okamura, Masami, Suzuki, Kazuaki, Shimanuki, Mami, Kimura, Kizuku, Yamada, Takuya, Ohyoshi, Takayuki, Kigoshi, Hideo
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract The total synthesis of biselide A based on our earlier strategy of synthesizing haterumalides is reported. The highlights of this approach are the use of regioselective enzymatic hydrolysis for the installation of a C20 oxygen functional group and an asymmetric aldol reaction for the stereoselective introduction of a C3 oxygen functional group.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0036-1588169