The Application of Multicomponent Ugi and Passerini Reactions for the One-Pot Synthesis of Pyrrolones and Butenolides

The Application of Multicomponent Ugi and Passerini Reactions for the One-Pot Synthesis of Pyrrolones and Butenolides

Abstract A new protocol for the one-pot synthesis of pyrrolones and butenolides involving an isocyanide-based multicomponent reaction (Ugi or Passerini) followed by a triethylamine-promoted cycloisomerization is described.

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Veröffentlicht in:Synthesis (Stuttgart) 2016-07, Vol.48 (14), p.2280-2286
Hauptverfasser: Nechaev, Anton A., Peshkov, Anatoly A., Peshkov, Vsevolod A., Van der Eycken, Erik V.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A new protocol for the one-pot synthesis of pyrrolones and butenolides involving an isocyanide-based multicomponent reaction (Ugi or Passerini) followed by a triethylamine-promoted cycloisomerization is described.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0035-1561422