Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one

Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one

Abstract A convenient procedure for the synthesis of very expensive ( R )-lactic acid from relatively inexpensive ( R )-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde– tert -butanol mixture.

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Veröffentlicht in:Synthesis (Stuttgart) 2015-06, Vol.47 (11), p.1557-1559
Hauptverfasser: Aitken, R. Alan, Meehan, Anna, Power, Lynn A.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A convenient procedure for the synthesis of very expensive ( R )-lactic acid from relatively inexpensive ( R )-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde– tert -butanol mixture.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0034-1380511