A Convenient Synthesis of 2-Fluoro- and 2-Chloromalonic Esters Mediated by Hypervalent Iodine
Abstract Direct fluorination of malonic esters with a reagent system of iodosylbenzene and Et 3 N·5HF gave the corresponding 2-fluoromalonic esters in good to high yields. Direct chlorination using iodosylbenzene and hydrochloric acid also provided the 2-chloromalonates in high yields.
Gespeichert in:
| Veröffentlicht in: | Synthesis (Stuttgart) 2015-10, Vol.47 (20), p.3241-3245 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | Abstract
Direct fluorination of malonic esters with a reagent system of iodosylbenzene and Et
3
N·5HF gave the corresponding 2-fluoromalonic esters in good to high yields. Direct chlorination using iodosylbenzene and hydrochloric acid also provided the 2-chloromalonates in high yields. |
|---|---|
| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-0034-1378747 |