Domino Reaction of 2,2-Dihydroxyindene-1,3-dione with Aromatic Amines: Efficient Synthesis of Isochromeno[4,3-b]indol-5(11H)-one Derivatives
Abstract An efficient approach to 16 examples of polyfunctionalized isochromeno[4,3- b ]indol-5(1 H )-one derivatives, obtained in 60–85% yield and with excellent regioselectivity, has been developed through a domino reaction of 2,2-dihydroxyindene-1,3-dione with aromatic amines under microwave irra...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2014-12, Vol.46 (23), p.3207-3212 |
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| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
An efficient approach to 16 examples of polyfunctionalized isochromeno[4,3-
b
]indol-5(1
H
)-one derivatives, obtained in 60–85% yield and with excellent regioselectivity, has been developed through a domino reaction of 2,2-dihydroxyindene-1,3-dione with aromatic amines under microwave irradiation. The atom- and step-economy and scope make this reaction a powerful tool for assembling polyheterocyclic scaffolds of general chemical and biomedical interest. |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-0034-1378617 |