Iodine-Catalyzed C–N Cleavage of Tertiary Amines: Synthesis of Methylene-Bridged Bis-1,3-dicarbonyl Compounds

Iodine-Catalyzed C–N Cleavage of Tertiary Amines: Synthesis of Methylene-Bridged Bis-1,3-dicarbonyl Compounds

Abstract A novel and efficient iodine-catalyzed C–N cleavage of tertiary amines via an sp 3 C–H bond oxidative coupling reaction is described. A wide range of methylene-bridged bis-1,3-dicarbonyl compounds were synthesized in up to 92% yield by using an environmentally benign catalytic system in com...

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Veröffentlicht in:Synthesis (Stuttgart) 2014-09, Vol.46 (18), p.2445-2450
Hauptverfasser: Lu, Lin, Guo, Shengmei, Xiong, Qiheng, Liu, Shengyi, Li, Xiang, Cai, Hu
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A novel and efficient iodine-catalyzed C–N cleavage of tertiary amines via an sp 3 C–H bond oxidative coupling reaction is described. A wide range of methylene-bridged bis-1,3-dicarbonyl compounds were synthesized in up to 92% yield by using an environmentally benign catalytic system in combination with 1,3-dicarbonyl compounds.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0034-1378208