Facile Synthesis of the Isoquinoline Alkaloids Doryanine and Oxyhydrastinine
Abstract Starting from 4,5-(methylenedioxy)homophthalic acid, a concise and efficient synthesis of the isoquinoline alkaloids doryanine and oxyhydrastinine is described via the corresponding homophthalimide utilizing a one-pot regioselective reductive dehydration and catalytic hydrogenation pathway.
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| Veröffentlicht in: | Synthesis (Stuttgart) 2014, Vol.46 (14), p.1954-1956 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
Starting from 4,5-(methylenedioxy)homophthalic acid, a concise and efficient synthesis of the isoquinoline alkaloids doryanine and oxyhydrastinine is described via the corresponding homophthalimide utilizing a one-pot regioselective reductive dehydration and catalytic hydrogenation pathway. |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-0033-1341158 |