Baicalein: An In Vitro Antigenotoxic Compound from Scutellaria baicalensis
Abstract Bioassay-guided fractionation of an H 2 O extract of the root of SCUTELLARIA BAICALENSIS has furnished an IN VITRO antigenotoxic flavonoid, baicalein (1) and 2’,5,5’,7-tetrahydroxy- 6’,8-dimethoxyflavone (2). Compound 1 exhibited a dose-dependent inhibition of aflatoxin B 1 (AFB 1 ) and N-m...
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| Veröffentlicht in: | Planta medica 2000-02, Vol.66 (1), p.70-71 |
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| container_end_page | 71 |
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| container_title | Planta medica |
| container_volume | 66 |
| creator | Lee, Byung-Hoon Lee, Sang-Jun Kang, Tai-Hyun Kim, Do-Hoon Sohn, Dong-Hwan Ko, Geon-Il Kim, Youn-Chul |
| description | Abstract
Bioassay-guided fractionation of an H
2
O extract of the root of SCUTELLARIA BAICALENSIS has furnished an IN VITRO antigenotoxic flavonoid, baicalein (1) and 2’,5,5’,7-tetrahydroxy- 6’,8-dimethoxyflavone (2). Compound 1 exhibited a dose-dependent inhibition of aflatoxin B
1
(AFB
1
) and N-methyl-N’-nitro-N- nitrosoguanidine mutagenicity in the SALMONELLA TYPHIMURIUM bacterial mutation assay. In the chromosome aberration assay, compound 1, at a concentration of 5µM, reduced the frequency of chromosome aberration induced by AFB
1
but increased the clastogenic effect of AFB
1
at a concentration of 50µM. |
| doi_str_mv | 10.1055/s-0029-1243111 |
| format | Article |
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Bioassay-guided fractionation of an H
2
O extract of the root of SCUTELLARIA BAICALENSIS has furnished an IN VITRO antigenotoxic flavonoid, baicalein (1) and 2’,5,5’,7-tetrahydroxy- 6’,8-dimethoxyflavone (2). Compound 1 exhibited a dose-dependent inhibition of aflatoxin B
1
(AFB
1
) and N-methyl-N’-nitro-N- nitrosoguanidine mutagenicity in the SALMONELLA TYPHIMURIUM bacterial mutation assay. In the chromosome aberration assay, compound 1, at a concentration of 5µM, reduced the frequency of chromosome aberration induced by AFB
1
but increased the clastogenic effect of AFB
1
at a concentration of 50µM.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-0029-1243111</identifier><identifier>PMID: 10705739</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Aflatoxin B1 - antagonists & inhibitors ; Antimutagenic Agents - isolation & purification ; Antimutagenic Agents - pharmacology ; Biological and medical sciences ; Flavanones ; Flavonoids - isolation & purification ; Flavonoids - pharmacology ; General pharmacology ; Letter ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plants, Medicinal - chemistry</subject><ispartof>Planta medica, 2000-02, Vol.66 (1), p.70-71</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-b0f4c5afe051c115f610433ecd5cac485688fafb5cd5bc71112586eb0c8846f83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0029-1243111.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0029-1243111$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3015,3016,27923,27924,54558,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1299754$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10705739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Byung-Hoon</creatorcontrib><creatorcontrib>Lee, Sang-Jun</creatorcontrib><creatorcontrib>Kang, Tai-Hyun</creatorcontrib><creatorcontrib>Kim, Do-Hoon</creatorcontrib><creatorcontrib>Sohn, Dong-Hwan</creatorcontrib><creatorcontrib>Ko, Geon-Il</creatorcontrib><creatorcontrib>Kim, Youn-Chul</creatorcontrib><title>Baicalein: An In Vitro Antigenotoxic Compound from Scutellaria baicalensis</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
Bioassay-guided fractionation of an H
2
O extract of the root of SCUTELLARIA BAICALENSIS has furnished an IN VITRO antigenotoxic flavonoid, baicalein (1) and 2’,5,5’,7-tetrahydroxy- 6’,8-dimethoxyflavone (2). Compound 1 exhibited a dose-dependent inhibition of aflatoxin B
1
(AFB
1
) and N-methyl-N’-nitro-N- nitrosoguanidine mutagenicity in the SALMONELLA TYPHIMURIUM bacterial mutation assay. In the chromosome aberration assay, compound 1, at a concentration of 5µM, reduced the frequency of chromosome aberration induced by AFB
1
but increased the clastogenic effect of AFB
1
at a concentration of 50µM.</description><subject>Aflatoxin B1 - antagonists & inhibitors</subject><subject>Antimutagenic Agents - isolation & purification</subject><subject>Antimutagenic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Flavanones</subject><subject>Flavonoids - isolation & purification</subject><subject>Flavonoids - pharmacology</subject><subject>General pharmacology</subject><subject>Letter</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EoqWwMqIMrC7XsZ04bFDxKKrEwGONHNcGV4ld2YkE_x5XqQQLk6-s892r7yB0TmBOgPOriAHyCpOcUULIAZoSRisMeU4O0RSA5hgqRifoJMYNAGEVwDGaECiBl7SaoqdbaZVstXXX2Y3Lli57t33wae7th3a-919WZQvfbf3g1pkJvste1NDrtpXByqwZ4y7aeIqOjGyjPtu_M_R2f_e6eMSr54fl4maFFeWixw0Yprg0GjhRhHBTEGCUarXmSiomeCGEkabh6aNRZWqVc1HoBpQQrDCCztB83KuCjzFoU2-D7WT4rgnUOyl1rHdS6r2UFLgYA9uh6fT6Dz5aSMDlHpAxtTFBOmXjL5dXVclZwvCI9Z9Wd7re-CG41PS_uz_LlHcv</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Lee, Byung-Hoon</creator><creator>Lee, Sang-Jun</creator><creator>Kang, Tai-Hyun</creator><creator>Kim, Do-Hoon</creator><creator>Sohn, Dong-Hwan</creator><creator>Ko, Geon-Il</creator><creator>Kim, Youn-Chul</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20000201</creationdate><title>Baicalein: An In Vitro Antigenotoxic Compound from Scutellaria baicalensis</title><author>Lee, Byung-Hoon ; Lee, Sang-Jun ; Kang, Tai-Hyun ; Kim, Do-Hoon ; Sohn, Dong-Hwan ; Ko, Geon-Il ; Kim, Youn-Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-b0f4c5afe051c115f610433ecd5cac485688fafb5cd5bc71112586eb0c8846f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aflatoxin B1 - antagonists & inhibitors</topic><topic>Antimutagenic Agents - isolation & purification</topic><topic>Antimutagenic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Flavanones</topic><topic>Flavonoids - isolation & purification</topic><topic>Flavonoids - pharmacology</topic><topic>General pharmacology</topic><topic>Letter</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Byung-Hoon</creatorcontrib><creatorcontrib>Lee, Sang-Jun</creatorcontrib><creatorcontrib>Kang, Tai-Hyun</creatorcontrib><creatorcontrib>Kim, Do-Hoon</creatorcontrib><creatorcontrib>Sohn, Dong-Hwan</creatorcontrib><creatorcontrib>Ko, Geon-Il</creatorcontrib><creatorcontrib>Kim, Youn-Chul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Byung-Hoon</au><au>Lee, Sang-Jun</au><au>Kang, Tai-Hyun</au><au>Kim, Do-Hoon</au><au>Sohn, Dong-Hwan</au><au>Ko, Geon-Il</au><au>Kim, Youn-Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Baicalein: An In Vitro Antigenotoxic Compound from Scutellaria baicalensis</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>66</volume><issue>1</issue><spage>70</spage><epage>71</epage><pages>70-71</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
Bioassay-guided fractionation of an H
2
O extract of the root of SCUTELLARIA BAICALENSIS has furnished an IN VITRO antigenotoxic flavonoid, baicalein (1) and 2’,5,5’,7-tetrahydroxy- 6’,8-dimethoxyflavone (2). Compound 1 exhibited a dose-dependent inhibition of aflatoxin B
1
(AFB
1
) and N-methyl-N’-nitro-N- nitrosoguanidine mutagenicity in the SALMONELLA TYPHIMURIUM bacterial mutation assay. In the chromosome aberration assay, compound 1, at a concentration of 5µM, reduced the frequency of chromosome aberration induced by AFB
1
but increased the clastogenic effect of AFB
1
at a concentration of 50µM.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>10705739</pmid><doi>10.1055/s-0029-1243111</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0032-0943 |
| ispartof | Planta medica, 2000-02, Vol.66 (1), p.70-71 |
| issn | 0032-0943 1439-0221 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Aflatoxin B1 - antagonists & inhibitors Antimutagenic Agents - isolation & purification Antimutagenic Agents - pharmacology Biological and medical sciences Flavanones Flavonoids - isolation & purification Flavonoids - pharmacology General pharmacology Letter Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry |
| title | Baicalein: An In Vitro Antigenotoxic Compound from Scutellaria baicalensis |
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