Baicalein: An In Vitro Antigenotoxic Compound from Scutellaria baicalensis

Abstract Bioassay-guided fractionation of an H 2 O extract of the root of SCUTELLARIA BAICALENSIS has furnished an IN VITRO antigenotoxic flavonoid, baicalein (1) and 2’,5,5’,7-tetrahydroxy- 6’,8-dimethoxyflavone (2). Compound 1 exhibited a dose-dependent inhibition of aflatoxin B 1 (AFB 1 ) and N-m...

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Veröffentlicht in:	Planta medica 2000-02, Vol.66 (1), p.70-71
Hauptverfasser:	Lee, Byung-Hoon, Lee, Sang-Jun, Kang, Tai-Hyun, Kim, Do-Hoon, Sohn, Dong-Hwan, Ko, Geon-Il, Kim, Youn-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxin B1 - antagonists & inhibitors Antimutagenic Agents - isolation & purification Antimutagenic Agents - pharmacology Biological and medical sciences Flavanones Flavonoids - isolation & purification Flavonoids - pharmacology General pharmacology Letter Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry
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Zusammenfassung:	Abstract Bioassay-guided fractionation of an H 2 O extract of the root of SCUTELLARIA BAICALENSIS has furnished an IN VITRO antigenotoxic flavonoid, baicalein (1) and 2’,5,5’,7-tetrahydroxy- 6’,8-dimethoxyflavone (2). Compound 1 exhibited a dose-dependent inhibition of aflatoxin B 1 (AFB 1 ) and N-methyl-N’-nitro-N- nitrosoguanidine mutagenicity in the SALMONELLA TYPHIMURIUM bacterial mutation assay. In the chromosome aberration assay, compound 1, at a concentration of 5µM, reduced the frequency of chromosome aberration induced by AFB 1 but increased the clastogenic effect of AFB 1 at a concentration of 50µM.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-0029-1243111