Chemistry and Biology of Acyloin Natural Products
This review details the isolation, biosynthesis, biological activity, and synthesis of α-hydroxy ketone (acyloin) natural products. The role of these compounds as biosynthetic precursors to complex natural products and synthetic strategies to access the sensitive acyloin moiety and stereochemistry a...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2023-08, Vol.55 (15), p.2273-2284 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | This review details the isolation, biosynthesis, biological activity, and synthesis of α-hydroxy ketone (acyloin) natural products. The role of these compounds as biosynthetic precursors to complex natural products and synthetic strategies to access the sensitive acyloin moiety and stereochemistry are highlighted.
1 Introduction
1.1 Xenocyloins
1.2 Biological Activity
1.3 Biosynthesis
1.4 Acyloins as Discoipyrrole Biosynthetic Precursors
2 Total Synthesis of Acyloin Natural Products
2.1 Kurasoins A and B
2.2 Soraphinol A and Circumcin B
2.3 4-Hydroxysattabacin and Actinopolymorphol A
2.4 Actinopolymorphol B
2.5 Sattazolins and Sattabacins
2.6 Catalyst Development and Application in Acyloin Synthesis
2.7 Xenocyloins
3 Conclusion |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/a-2004-1228 |