Gram-Scale Synthesis of Substituted Triarylmethanes
Abstract A high-yield, open-vessel route for the facile-operational, gram-scale synthesis of functionalized triarylmethanes (TRAMs) is described via silica-coated magnetic nanoparticles of modified polyphosphoric acid (NiFe 2 O 4 @SiO 2 -PPA)-mediated intermolecular Friedel–Crafts reaction of sub...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2022-10, Vol.54 (20), p.4561-4575 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
A high-yield, open-vessel route for the facile-operational, gram-scale synthesis of functionalized triarylmethanes (TRAMs) is described via silica-coated magnetic nanoparticles of modified polyphosphoric acid (NiFe
2
O
4
@SiO
2
-PPA)-mediated intermolecular Friedel–Crafts reaction of substituted aryl aldehydes with 2 equivalents of oxygenated arenes under environmentally friendly reaction conditions. Among the overall reaction process, only water was generated as the by-product. Various reaction conditions are investigated for efficient transformation. |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/a-1863-3443 |