Synthesis of P- and S-Stereogenic Compounds via Enantioselective C–H Functionalization

Abstract Transition metal-catalyzed enantioselective C–H functionalization has emerged as an efficient and powerful strategy to access various chiral molecules. Recently, this strategy has also provided a complementary pathway to the construction of P - and S -stereogenic compounds. In this short review, we summarize the development and applications of various catalytic systems: Pd(II)/mono- N -protected amino acids (MPAA), Pd(0)/trivalent phosphorus chiral ligands, chiral cyclopentadienyl-ligated metal catalysts [Cp x M(III)] (M = Rh, Ir), half-sandwich d 6 Ir(III) and Ru(II) with a chiral carboxylic acid (CCA) ligand, Ir(I)/chiral bidentate boryl ligand, and Ir(I)/chiral cation, for accessing these chiral compounds via enantioselective C–H functionalization. 1 Introduction 2 Pd(II)/Mono- N -protected Amino Acids 3 Pd(0)/Trivalent Phosphorus Chiral Ligands 4 Chiral Cyclopentadienyl-Ligated Metal Catalysts [Cp x M(III)] (M = Rh, Ir) 5 Half-sandwich d 6 Ir(III) and Ru(II) with a Chiral Carboxylic Acid (CCA) Ligand 6 Ir(I)/Chiral Bidentate Boryl Ligand 7 Ir(I)/Chiral Cation 8 Conclusion and Outlook