Rh(III)-Catalyzed Tandem [4+2] Annulation To Construct Functional Dihydroisoquinolinones

Rh(III)-Catalyzed Tandem [4+2] Annulation To Construct Functional Dihydroisoquinolinones

Abstract A highly efficient Rh(III)-catalyzed tandem [4+2] annulation to construct functional dihydroisoquinolinone derivatives with an alkenyl side chain by insertion into an N–O bond as an internal oxidation process has been achieved. A wide range of 1,3-dienes as the coupling partners makes this...

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Veröffentlicht in:Synthesis (Stuttgart) 2022-07, Vol.54 (14), p.3271-3281
Hauptverfasser: Yang, Jia-Hui, Dong, Lin
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A highly efficient Rh(III)-catalyzed tandem [4+2] annulation to construct functional dihydroisoquinolinone derivatives with an alkenyl side chain by insertion into an N–O bond as an internal oxidation process has been achieved. A wide range of 1,3-dienes as the coupling partners makes this simple methodology even more useful.
ISSN:0039-7881
1437-210X
DOI:10.1055/a-1787-3958