Solvent- and Metal-Controlled Regiodivergent Synthesis of Tri­fluoromethylated Pyrazol-3-yl- and Pyrazol-5-ylphosphonates

Solvent- and Metal-Controlled Regiodivergent Synthesis of Tri­fluoromethylated Pyrazol-3-yl- and Pyrazol-5-ylphosphonates

Abstract Convenient approaches to the selective syntheses of trifluoro­methylated pyrazol-3-yl- and pyrazol-5-ylphosphonates have been developed based on solvent- and metal-controlled reaction of diethyl (4,4,4-trifluoro-3-oxobut-1-yn-1-yl)phosphonate and monosubstituted hydrazines.

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Veröffentlicht in:Synthesis (Stuttgart) 2022-03, Vol.54 (6), p.1652-1660
Hauptverfasser: Mitrofanov, Alexander Yu, Bychkova, Valentina A., Kalugin, Danila A., Beletskaya, Irina P.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Convenient approaches to the selective syntheses of trifluoro­methylated pyrazol-3-yl- and pyrazol-5-ylphosphonates have been developed based on solvent- and metal-controlled reaction of diethyl (4,4,4-trifluoro-3-oxobut-1-yn-1-yl)phosphonate and monosubstituted hydrazines.
ISSN:0039-7881
1437-210X
DOI:10.1055/a-1690-4840