Synthesis of Benzo-Fused Cyclic Compounds via Rhodium-Catalyzed Decarboxylative Coupling of Aromatic Carboxylic Acids with Alkynes

Abstract The decarboxylative coupling of diversely substituted benzoic acids with internal alkynes proceeds smoothly in the presence of a [RhCl(cod)] 2 /1,2,3,4-tetraphenyl-1,3-cyclopentadiene catalyst system to selectively produce highly substituted naphthalene derivatives. The catalyst system is a...

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Veröffentlicht in:Synthesis (Stuttgart) 2021-09, Vol.53 (17), p.3029-3036
Hauptverfasser: Inai, Yasuhito, Usuki, Yoshinosuke, Satoh, Tetsuya
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract The decarboxylative coupling of diversely substituted benzoic acids with internal alkynes proceeds smoothly in the presence of a [RhCl(cod)] 2 /1,2,3,4-tetraphenyl-1,3-cyclopentadiene catalyst system to selectively produce highly substituted naphthalene derivatives. The catalyst system is applicable to constructing anthracene and benzo­[ c ]thiophene frameworks through reactions of naphthoic and thiophene-2-carboxylic acids, respectively.
ISSN:0039-7881
1437-210X
DOI:10.1055/a-1416-6997