C2-gem-Aryldifluoromethylation of Quinoline N-Oxides with Potassium 2,2-Difluoro-2-arylacetates under Transition-Metal-Free Conditions

Abstract A simple protocol for C2- gem -aryldifluoromethylation of quinoline N -oxides with potassium 2,2-difluoro-2-arylacetates has been developed, affording C2- gem -aryldifluoromethylated quinoline N -oxides bearing different functional groups in moderate to good yields. Moreover, experimental studies reveal that this reaction is likely to proceed through a radical pathway.