Antibiotic prophylaxis and the risk of C lostridium difficile -associated diarrhoea

Antibiotic prophylaxis and the risk of C lostridium difficile -associated diarrhoea

To test the hypothesis that extended antibiotic prophylaxis increases the risk of Clostridium difficile -associated diarrhoea (CDAD), we conducted a retrospective cohort study of 2641 patients under-going cardiovascular surgery. Main outcome measures were the duration of prophylaxis (48h) and the oc...

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Veröffentlicht in:The Journal of hospital infection 2001-06, Vol.48 (2), p.93-97
Hauptverfasser: Harbarth, S., Samore, M.H., Carmeli, Y.
Format: Artikel
Sprache:eng
Schlagworte:
antimicrobial prophylaxis
Clostridium difficile
Coronary bypass surgery
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Zusammenfassung:To test the hypothesis that extended antibiotic prophylaxis increases the risk of Clostridium difficile -associated diarrhoea (CDAD), we conducted a retrospective cohort study of 2641 patients under-going cardiovascular surgery. Main outcome measures were the duration of prophylaxis (48h) and the occurrence of CDAD. CDAD occurred in 31 patients (1.2%), who were significantly older (70±9 y vs. 66±10 y;P=0.03), received more therapeutic antibiotics (2.2±1.9 vs. 0.4±0.9;P=0.001) and had a longer postoperative hospital stay (26±19 d vs. 9±8 d;P
ISSN:0195-6701
1532-2939
DOI:10.1053/jhin.2001.0951