Occupational radiation exposure and genetic polymorphisms in DNA repair genes

Occupational radiation exposure and genetic polymorphisms in DNA repair genes

Radiation sensitivity appears to be influenced by genetic polymorphisms in some DNA repair genes and individuals with low DNA repair capacity can be at increased risk of developing cancer. The aim of the present study was to determine the impact of gene polymorphisms on DNA damages in the form of mi...

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Veröffentlicht in:Radioprotection 2017-10, Vol.52 (4), p.241-249
Hauptverfasser: Zakeri, F., Farshidpour, M.R., Rajabpour, M.R.
Format: Artikel
Sprache:eng
Schlagworte:
cytogenetic
DNA
genetic effect
low doses
occupational exposure
radiation
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Zusammenfassung:Radiation sensitivity appears to be influenced by genetic polymorphisms in some DNA repair genes and individuals with low DNA repair capacity can be at increased risk of developing cancer. The aim of the present study was to determine the impact of gene polymorphisms on DNA damages in the form of micronuclei (MN) in circulating lymphocytes of interventional cardiologists (ICs), occupationally exposed to ionizing radiation. MN frequency was significantly higher in the ICs than in the controls (27.7 ± 17.2‰ vs. 8.0 ± 2.6‰, p 
ISSN:0033-8451
1769-700X
DOI:10.1051/radiopro/2017025