2-O-alkylated para-benzamide α-helix mimetics: the role of scaffold curvature

2-O-alkylated para-benzamide α-helix mimetics: the role of scaffold curvature

The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.

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Veröffentlicht in:Organic & biomolecular chemistry 2012-08, Vol.10 (32), p.6469
Hauptverfasser: Azzarito, Valeria, Prabhakaran, Panchami, Bartlett, Alice I, Murphy, Natasha S, Hardie, Michaele J, Kilner, Colin A, Edwards, Thomas A, Warriner, Stuart L, Wilson, Andrew J
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Benzamides - chemistry
Biomimetics
Drug Design
Inhibitory Concentration 50
Models, Molecular
Molecular Mimicry
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Zusammenfassung:The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob26262b