Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

Specific interactions were introduced between an artificial heptad repeat peptide template and HIV-1 gp41 for fusion inhibitor design, using a structure based rational design strategy. The designed peptides are nonhomologous with naturally occurring peptide and protein sequences, specifically intera...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2012-12, Vol.48 (94), p.11579
Hauptverfasser:	Shi, Weiguo, Cai, Lifeng, Lu, Lu, Wang, Chao, Wang, Kun, Xu, Liang, Zhang, Sha, Han, Han, Jiang, Xifeng, Zheng, Baohua, Jiang, Shibo, Liu, Keliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Drug Design HIV Envelope Protein gp41 - chemistry HIV-1 - drug effects HIV-1 - physiology Molecular Sequence Data Peptidomimetics - chemistry Peptidomimetics - pharmacology Repetitive Sequences, Amino Acid Virus Internalization - drug effects
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Beschreibung
Zusammenfassung:	Specific interactions were introduced between an artificial heptad repeat peptide template and HIV-1 gp41 for fusion inhibitor design, using a structure based rational design strategy. The designed peptides are nonhomologous with naturally occurring peptide and protein sequences, specifically interact with HIV-1 gp41, and show strong anti-HIV activity.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c2cc35973a